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Literature summary extracted from

  • Zempleni, J.; Wijeratne, S.S.; Hassan, Y.I.
    Biotin (2009), Biofactors, 35, 36-46.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.10 Mg2+
-
 Homo sapiens
6.3.4.15 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl-CoA carboxylase] Homo sapiens
-
 AMP + diphosphate + propionyl-CoA carboxylase
-
 ?
6.3.4.10 additional information Homo sapiens holocarboxylase synthetase catalyzes the attachment of biotin to the epsilon-amino group of a specific lysine residue in apocarboxylases, biotinylation of biotin-dependent carboxylases requires ATP and proceeds in the following two steps ?
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 1] Homo sapiens cytoplasmic acetyl-CoA carboxylase isozyme AMP + diphosphate + acetyl-CoA carboxylase 1
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 2] Homo sapiens mitochondrial acetyl-CoA carboxylase isozyme AMP + diphosphate + acetyl-CoA carboxylase 2
-
 ?
6.3.4.15 additional information Homo sapiens holocarboxylase synthetase catalyzes the attachment of biotin to the epsilon-amino group of a specific lysine residue in apocarboxylases, biotinylation of biotin-dependent carboxylases requires ATP and proceeds in the following two steps ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.10 Homo sapiens
-
-
-
6.3.4.15 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl-CoA carboxylase]
-
 Homo sapiens AMP + diphosphate + propionyl-CoA carboxylase
-
 ?
6.3.4.10 additional information holocarboxylase synthetase catalyzes the attachment of biotin to the epsilon-amino group of a specific lysine residue in apocarboxylases, biotinylation of biotin-dependent carboxylases requires ATP and proceeds in the following two steps Homo sapiens ?
-
 ?
6.3.4.10 additional information the 4'-hydroxyazobenzene-2-carboxylic acid dye assay can be used to quantify biotin Homo sapiens ?
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 1] cytoplasmic acetyl-CoA carboxylase isozyme Homo sapiens AMP + diphosphate + acetyl-CoA carboxylase 1
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 2] mitochondrial acetyl-CoA carboxylase isozyme Homo sapiens AMP + diphosphate + acetyl-CoA carboxylase 2
-
 ?
6.3.4.15 ATP + biotin + apo-[propionyl-CoA carboxylase]
-
 Homo sapiens AMP + diphosphate + propionyl-CoA carboxylase
-
 ?
6.3.4.15 additional information holocarboxylase synthetase catalyzes the attachment of biotin to the epsilon-amino group of a specific lysine residue in apocarboxylases, biotinylation of biotin-dependent carboxylases requires ATP and proceeds in the following two steps Homo sapiens ?
-
 ?
6.3.4.15 additional information the 4'-hydroxyazobenzene-2-carboxylic acid dye assay can be used to quantify biotin Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.10 HCS
-
 Homo sapiens
6.3.4.10 Holocarboxylase synthetase
-
 Homo sapiens
6.3.4.15 HCS
-
 Homo sapiens
6.3.4.15 Holocarboxylase synthetase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.10 ATP
-
 Homo sapiens
6.3.4.15 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.3.4.10 malfunction biotin deficiency, e.g. occuring in patients with BTD deficiency, in severely malnourished children in developing countries, and in individuals consuming large amounts of raw egg white which contains the protein avidin, has adverse effects on cellular and humoral immune functions, and it can lead to candida dermatitis and presented with absent delayed-hypersensitivity skin-tests responses, IgA deficiency, and subnormal percentages of T-lymphocytes in peripheral blood, overview Homo sapiens
6.3.4.10 metabolism the enzyme is involved in the biotin metabolism, detailed overview Homo sapiens
6.3.4.15 malfunction biotin deficiency, e.g. occuring in patients with BTD deficiency, in severely malnourished children in developing countries, and in individuals consuming large amounts of raw egg white which contains the protein avidin, has adverse effects on cellular and humoral immune functions, and it can lead to candida dermatitis and presented with absent delayed-hypersensitivity skin-tests responses, IgA deficiency, and subnormal percentages of T-lymphocytes in peripheral blood, overview Homo sapiens
6.3.4.15 metabolism the enzyme is involved in the biotin metabolism, detailed overview Homo sapiens